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Genome editing with precision - The Harvard Gazette
A team from the Broad Institute of MIT and Harvard has developed a new CRISPR genome-editing approach that has the potential to correct up to 89 percent of known disease-causing genetic variations.
Researchers have combined two of the most important proteins in molecular biology — CRISPR-Cas9 and a reverse transcriptase — into a single machine. The system, called prime editing, is capable of directly editing human cells in a precise, efficient, and highly versatile fashion.
“A major aspiration in the molecular life sciences is the ability to precisely make any change to the genome in any location. We think prime editing brings us closer to that goal,” said David Liu, core institute member, Richard Merkin Professor, vice chair of the faculty, and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute of MIT and Harvard. “We’re not aware of another editing technology in mammalian cells that offers this level of versatility and precision with so few byproducts.”
A team from the Broad Institute of MIT and Harvard has developed a new CRISPR genome-editing approach that has the potential to correct up to 89 percent of known disease-causing genetic variations.
Researchers have combined two of the most important proteins in molecular biology — CRISPR-Cas9 and a reverse transcriptase — into a single machine. The system, called prime editing, is capable of directly editing human cells in a precise, efficient, and highly versatile fashion.
“A major aspiration in the molecular life sciences is the ability to precisely make any change to the genome in any location. We think prime editing brings us closer to that goal,” said David Liu, core institute member, Richard Merkin Professor, vice chair of the faculty, and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute of MIT and Harvard. “We’re not aware of another editing technology in mammalian cells that offers this level of versatility and precision with so few byproducts.”