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Breakthrough within reach for diabetes scientist and patients nearest to his heart
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<blockquote data-quote="cheryl" data-source="post: 3014" data-attributes="member: 1"><p><a href="https://news.harvard.edu/gazette/story/2021/11/harvard-diabetes-researcher-details-science-behind-potential-breakthrough/" target="_blank"><strong>Breakthrough within reach for diabetes scientist and patients nearest to his heart - Harvard</strong></a></p><p></p><p><strong>100 years after discovery of insulin, replacement therapy represents ‘a new kind of medicine,’ says Stem Cell Institute co-director Douglas Melton, whose children inspired his research</strong></p><p></p><p>When Vertex Pharmaceuticals announced last month that its investigational stem-cell-derived replacement therapy was, in conjunction with immunosuppressive therapy, helping the first patient in a Phase 1/2 clinical trial robustly reproduce his or her own fully differentiated pancreatic islet cells, the cells that produce insulin, the news was hailed as a potential breakthrough for the treatment of Type 1 diabetes. For Harvard Stem Cell Institute Co-Director and Xander University Professor Douglas Melton, whose lab pioneered the science behind the therapy, the trial marked the most recent turning point in a decades-long effort to understand and treat the disease. In a conversation with the Gazette, Melton discussed the science behind the advance, the challenges ahead, and the personal side of his research. The interview was edited for clarity and length.</p><p></p><p>GAZETTE: What is the significance of the Vertex trial?</p><p></p><p><strong>MELTON: </strong>The first major change in the treatment of Type 1 diabetes was probably the discovery of insulin in 1920. Now it’s 100 years later and if this works, it’s going to change the medical treatment for people with diabetes. Instead of injecting insulin, patients will get cells that will be their own insulin factories. It’s a new kind of medicine.</p></blockquote><p></p>
[QUOTE="cheryl, post: 3014, member: 1"] [URL='https://news.harvard.edu/gazette/story/2021/11/harvard-diabetes-researcher-details-science-behind-potential-breakthrough/'][B]Breakthrough within reach for diabetes scientist and patients nearest to his heart - Harvard[/B][/URL] [B]100 years after discovery of insulin, replacement therapy represents ‘a new kind of medicine,’ says Stem Cell Institute co-director Douglas Melton, whose children inspired his research[/B] When Vertex Pharmaceuticals announced last month that its investigational stem-cell-derived replacement therapy was, in conjunction with immunosuppressive therapy, helping the first patient in a Phase 1/2 clinical trial robustly reproduce his or her own fully differentiated pancreatic islet cells, the cells that produce insulin, the news was hailed as a potential breakthrough for the treatment of Type 1 diabetes. For Harvard Stem Cell Institute Co-Director and Xander University Professor Douglas Melton, whose lab pioneered the science behind the therapy, the trial marked the most recent turning point in a decades-long effort to understand and treat the disease. In a conversation with the Gazette, Melton discussed the science behind the advance, the challenges ahead, and the personal side of his research. The interview was edited for clarity and length. GAZETTE: What is the significance of the Vertex trial? [B]MELTON: [/B]The first major change in the treatment of Type 1 diabetes was probably the discovery of insulin in 1920. Now it’s 100 years later and if this works, it’s going to change the medical treatment for people with diabetes. Instead of injecting insulin, patients will get cells that will be their own insulin factories. It’s a new kind of medicine. [/QUOTE]
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Breakthrough within reach for diabetes scientist and patients nearest to his heart
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